Saturday, June 2, 2012

Endocrine system

Figure 1. Glands of the Endocrine system
The endocrine system is the system of specialized organs called glands, each of which secretes a type of chemical called a hormone directly into the bloodstream to regulate the body. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target organ may be affected by more than one hormone.

Hormones regulate and influence:
  • Weight Regulation
  • Your Immune Function
  • Body Fat Composition
  • Energy Levels
  • Anti-aging
  • Regulating Mood
  • Sexual Function
  • Reproductive Processes
  • Growth rate
  • Tissue Function
  • Metabolism


The hormones secreted by the endocrine system are classified into three categories based on their chemical structure:
  1. Steroids – these hormones are lipids made from cholesterol, such as sex hormones. They come from the testis (male), ovaries (female), adrenal glands and placenta.
  2. Peptides –  are short chains of amino acids that are secreted by the pituitary gland, parathyroid gland, heart, stomach, liver, and kidneys.  Most hormones are peptides.
  3. Amines – these are made from an amino acid secreted from the thyroid gland and adrenal glands.



glands
HORMONES
GLAND/HORMONE FUNCTION
SOME DISORDERS
Hypothalamus
(Lower middle of the brain)
Growth hormone-releasing hormone (GHRH)

Thyrotropin-releasing hormone (TRH)

Corticotropin-releasing hormone (CRH)

Gonadotropin-releasing hormone (GnRH)

Prolactin-(PRL)


Antidiuretic Hormones- (ADH)
Communicates with both nervous and endocrine systems.

Stimulates (GHRH, TRH, CRH, GnRH) or inhibits (PIF) hormone production in the pituitary










Water balance
















Precocious puberty (early GnRH production)

Kallman syndrome (inadequate GnRH production)
Pituitary
(below hypothalamus, behind sinus cavity)
Prolactin







Growth Hormone





ACTH


TSH



LH, FSH
Milk production
Bone growth












Stimulates cortisol


Stimulates thyroid
Regulation of testosterone and estrogen, fertility
Hypopituitarism
   Empty Sella Syndrome
   Galactorrhea




Acromegaly or Gigantism (excess GH)
Growth Hormone Deficiency (GHD)


Cushing disease (excess ACTH)


Hyper/Hypothyroidism (TSH)


Loss of menstrual period

Loss of sex drive

Infertility


Thyroid
(butterfly shaped,
Lies flat against windpipe in the throat)
T4 (thyroxine)
T3 (triiodothyronine)


calcitonin
Metabolism




Regulate blood in calcium
Thyroid diseases (including hypo and hyperthyroidism)
Parathyroid
(located above or next to thyroid)
Parathyroid Hormone (PTH)  or Parathormone

Hyperparathyroidism

Hypoparathyroidism

Adrenal   
(2 organs on top of kidneys)
Epinephrine

Norepinephrine

Aldosterone 


Cortisol
Blood pressure regulation

stress reaction

Salt, water balance


Stress reaction

Pheochromocytopenia(MEN2)

Conn syndrome

Cushing syndrome


Addisons disease
Ovaries
(located on the pelvis)
Estrogen

Progesterone
Female sexual characteristics
Polycystic ovary syndrome (PCOS)
Testes
(located in the groin)
Testosterone
Male sexual characteristics
Hypogonadism
Pancreas
(located behind the stomach)
Insulin
Glucagon
Somatostatin
Glucose regulation   
Diabetes mellitus

MENI

Zollinger-Ellison syndrome


Pineal
(lower side of the brain)
Melatonin
Helps control sleep patterns



References:
http://en.wikipedia.org/wiki/Endocrine_system
http://kidshealth.org/teen/your_body/body_basics/endocrine.html#
http://www.buzzle.com/articles/endocrine-system-function.html